Dpp1 5 29996ru full 02 12 2011 – 7 6 – ar


valid until 2018/1/23

Dpp1 5 29996ru full 02 12 2011

Dpp1 5 29996ru full 02 12 2011

Dpp1 5 29996ru full 02 12 2011

Dpp1 5 29996ru full 02 12 2011

21.01.2018 – Abstract Two novel TiO 2 sensitizers, based on the highly stable diketopyrrolopyrrole DPP skeleton, have been synthesized for application in the field of dye sensitized solar cells. Keep up the good work Mike Levine and crew. This approach also identified a number.

Dpp1 5 29996ru full 02 12 2011 946 04800a

What’s New?

1. 6Great article Mike and crew! Our final confirmation of the tremendous towing performance and potential of the 5.
2. 4 So the mileage figures are deceiving.http://softik.org/abbyy-finereader-11-0-110-121-professional-edition/We averaged between 13 mpg and 17 mpg depending on traffic conditions, surface streets and highway driving.

3. 4 Your articles are the best in the field! A truck that drives this smoothly and comfortably, with very little driver fatigue, at max capacities is something quite special — even unusual in any truck segment. http://softik.org/any-dvd-shrink-1-3-5portable/ http://softik.org/any-dvd-shrink-1-3-6-serial-fugitive/Number of Hits and Downloads for This Article. New competitive technology always brings out the best from all manufacturers for future products.

Top Rated Free Tube Sites:

4. 4 Proteins in the CM with. Thanks Mike for the write up.Dpp1 5 29996ru full 02 12 2011Inflammatory cytokines patterns in the placenta of pregnancies complicated by. Annexin A2 localized to iEVT in decidua basa.

5. 1 It all started with him having to replace the intake on his old Crown Vic police car. Prior to implantation and in.

6. 10 Profilin 1 localised to iEVT in decidua basalis.

7. 9 In this study, proDPP1 was up-regulated by.

Dpp1 5 29996ru full 02 12 2011 online security aswwebrepie64

By Mike Levine and Mark Williams. Last year, the Ford F offered most buyers a choice of legacy two-valve and three-valve 4. But our time with the fresh 5. In less than a week, we drove it miles — miles of which it towed a 9,pound conventional tandem axle horse trailer.

The four-valve per cylinder, dual overhead cam 5. In the regular cab, it can pull up to 10, pounds instead of a maximum 11, pounds. The optional chrome package added brightwork that included side steps and wheel covers.

Despite a lack of luxury items, the XLT F was more than comfortable inside. We turned our phone into a substitute for satellite radio by using Sync and Pandora to stream tunes wirelessly over Bluetooth, though we had to pair the phone and truck twice after the F stopped playing music this way.

It includes apps that provide full details about towing, off-roading, fuel economy and more. Controls on the steering wheel make short work of finding the information you want quickly and with minimal distraction.

But making up for the so-so mileage was an optional gallon fuel tank that gave us peace of mind and extra range pulling the heavy trailer. For comparison, the premium EcoBoost V-6 F is only available with full gallon reservoir.

In our first stretch of towing — miles from Norco to Needles, Calif. As we left the L. It was available 29996ru demand. On the steepest parts of Cajon, we had no problem keeping up with traffic at around 65 mph with the modest 3.

When the engine needed more power, its six-speed transmission smoothly downshifted to 3rd gear, and the mill found its sweet spot at around 4, rpm. The truck never lost momentum.

In fact, it gained speed to the point where we had to ease back on the accelerator. After cresting the top of the grade, the truck quickly upshifted into 29996ru at 1, rpm and 65 mph.

We noticed some interesting transmission behavior as the terrain flattened out. The transmission holds gears longer when the truck is working hard to keep power up, and it downshifts automatically to slow the truck with a tap of the brake pedal on descents.

Every cog swap was carlike, but several times after upshifting into 6th, we felt the torque converter lock up about 20 seconds after the gear change. Another trait we noticed as we requested more power from the engine on climbs and to pass traffic was its split personality — similar to that of the 3.

Loping along, the V-8 was subdued and quiet. But when we needed more power, the exhaust note snarled like a sports car — not surprising, since the engine is also shared with the Ford Mustang.

We loved the deep notes it made. The F also features standard volt electric power-assisted steering for every engine except the 6. The limited-volume Chevy Silverado Hybrid uses a volt system.

The steering feels light when the truck is stopped and during low-speed maneuvers. It dynamically adjusts steering effort to match the speed and loads the truck is under. On dpp1 highway, the steering was precise and provided excellent driver feedback.

As dpp1 drove across the desert, we encountered strong winds that had knocked several semis off 29996ru highway the day before. While we could feel the gusts buffeting the truck and trailer, we never felt control was an issue.

Trailer-sway control senses difference in yaw between truck and trailer and uses the wheel brakes in both vehicles to counteract any sway before it becomes dangerous enough to throw the rig off the road.

A local dealer had to add the controller after it arrived for our test. Our turnaround point for our road test was near Laughlin, Nev. Cajon Pass was a warm-up for testing the 5. On Highway 68, the 5.

We also staked out a 7,foot stretch of the grade where we could safely climb the hill from a full stop and measure its performance using our VBOX kit. Zero to 60 mph up the steady 5 percent grade took Those numbers, plus seat-of-the-pants feel, make us wonder how much Ford might be sandbagging the 5.

We also ran the same performance tests on level ground. The zero-to mph time with the trailer was cut almost in half, to just Our final confirmation of the tremendous towing performance and potential of the 5.

At the rear wheels, we measured a very healthy hp and pounds-feet of torque. A truck that drives this smoothly and comfortably, with very little driver fatigue, at max capacities is something quite special — even unusual in any truck segment.

The truck was also comfortable and relatively easy to manage in unloaded driving around Los Angeles. It was also fun to show off some of the 5. We averaged between 13 mpg and 17 mpg depending on traffic conditions, surface streets and highway driving.

Which engine should F buyers choose? If we were going to buy an F today, the 5. WOW is all I can say Mike I want this truck so bad. I have to wait 8 more months until I can get something new but I’m pretty sure I know what its going to be now.

This is why I love this site. Keep up the good work! Ford is really stepping up their powertrain program. Never have been a true Ford fan full i will give them credit for putting out not just 1, but 4 impressive powertrain options.

Thanks Mike for the write up. A really nice looking truck with what sounds like to be a good engine, but the picture of the engine makes it look like it’s on life support with all those hoses.

I have to disagree with one thing – that if you are towing 5, lbs dpp1 and unsure of the EcoBoost the 5L is for you. Most crew cab half tons do not have that much payload, and the truck still needs to hold the people.

And you haven’t put anything in 2011 cab or bed. If you have lb payload. That leaves only lbs for passengers and cargo. Maybe 2011 I was towing up to lbs occasionally, didn’t have many passengers or cargo to weigh me down, didn’t care about fuel economy, and was afraid of EB I don’t know why I would be I would go with the 5L.

The ecoboost IS Ford’s max tow engine. It is advertised as being the workhorse of the bunch. The torture tests show that it can handle the work. You appear to be from the school “that there is no displacement for replacement”.

That is your personal opinion and that is fine, but a journalist is suppose to be open minded and you have made this statement without even doing a comparsion test on the ecoboost. Your reports at pickuptrucks.

On the strength of your light duty shoot out I bought a 3. Now I really wish I had bought the 5. All it is, is a modern engine in a sea of dated ones. And the truck is far too ugly and overpriced to be taken seriously.

Are you kidding me? And on the MPG figures, one must keep in mind that Ford did not come to that mileage figure using 3. They used the tallest gear offered which is a 3. So the mileage figures are deceiving.

My truck will mostly be a daily driver but also horse hauler. The real problem of the 5L without the max tow package is the payload on the Supercrew, especially the 6. You 2011 at least pounds more payload with EB Maxt Tow, pounds more with a supercab, which is the limiting towing factor for almost all trucks.

Oh, and then there is the wife, kids, firewood, bed cover, tools, cargo, etc that goes in the truck. I also heard Mike say EcoBoost might be better in high altitude than the V8’s, and when looking at the 6.

Carl What about this review made you feel as though this was an attack against the Ecoboost? Mike acknowledge the capibility of the Ecoboost and even recommeded it as well.

He’s just stating that the 5. And to say this new Ford engine is not impressive just show’s that you really are nothing more than a troll. I’ve been keeping up with this engine on Ford Truck Fourms and many personal owners of this truck are achiveing between mpg around town and up to 23mpg on the high And if you don’t beleive me why don’t you read the fourms for yourself.

That’s pretty impressive that the 5. While I’m sure the 6. They’ve still got the Ecoboost and their own 6. It’s also worth mentioning that it beat the Tundra with 5. All we needed was a EB, a Ford 6.

Also another thing I was curious about

Hide dpp1 5 29996ru full 02 12 2011 windows bit full

In the regular cab, it can pull up to 10, pounds instead of a maximum 11, pounds. Decidualization involves the categorical. Recently, Godbole [18] reported enhanced invasion of the. To standardize the degree of. Proteomic analyses of normal and PE placentas [23], syncytiotrophoblasts [24], cytotrophoblasts, deciduas [28]and plasmas [29,30] have been previously reported.

Dpp1 5 29996ru full 02 12 2011 for

Thus, evaluation of biopsy specimens from representative areas is important in establishing the existence of epithelial dysplasia or carcinoma along with clinical evolution[ 15 ]. Recent reviews on PVL have considered lesions with lichenoid aspects that progress to classical PVL phenotype in addition to the clinical aspect of multiple hyperkeratotic white plates with verrucous and expansive nature[ 6 , 7 , 16 ].

Four histological features are encountered over the course of the disease: Hyperplasia and hyperkeratosis with no epithelial dysplasia; multifocal expansion of lesions with or without varied grade of dysplasia; verrucous hyperplasia; and verrucous carcinoma or frankly invasive oral squamous cell carcinoma OSCC [ 5 – 7 ].

Nevertheless, not all lesions present with histopathological progression involving verrucous hyperplasia and verrucous carcinoma before OSCC. Currently, four main stages may be encountered during PVL development: Initial focal involvement, geographic expansion multifocal over time, development of a warty appearance and finally, development of a cancer[ 6 , 7 ].

Despite well-accepted clinical and histopathological features, the underlying molecular aspects involved in the pathogenesis and progression of PVL are still unknown and need further investigation.

An intriguing characteristic of this entity is the prevalence in older women with no exposition to known etiological factors for leukoplakia, including tobacco and alcohol consumption, suggesting a possible existence of active molecular events[ 17 ].

PVL lesions with mild or moderate dysplasia, in addition to lesions that progressed to OSCC, had high expression of Mcm-2 and Mcm-5; such molecular indicators may be useful as markers of malignant transformation of the disease, especially Mcm-2[ 3 , 5 ].

Similar findings detected in other conventional dysplastic premalignant lesions and OSCC have reinforced the aggressive nature of this entity, but without clarifying the true meaning of these molecules with respect to the pathogenesis or progression of PVL[ 7 , 20 ].

Recently, the use of proteomic-based mass spectrometry MS has increased interest in salivary biomarkers for numerous diseases, including OSCC[ 21 , 22 ]. Our interest in the salivary proteome – studied here – stems from the biochemical aspects of proteins, which are considered the most important molecules in the salivary fluid[ 22 , 23 ].

Salivary protein activity provides important information about the pathogenesis of many oral diseases; in addition, they have presented growing potential to revolutionise the field of etiopathogenesis and diagnosis[ 23 , 24 ].

Therefore, the objective of this survey was to elucidate a salivary proteome profile of sample with PVL using MS technology, in order to identify proteins that may be involved in the etiology of PVL.

This study followed the guidelines of the Declaration of Helsinki and Tokyo for research in humans, and have been approved by the local ethics board of the University of Campinas protocol number: All patients received verbal explanations concerning the study before signing a written informed consent.

In this study, 15 patients with diagnosed PVL-according to clinical and microscopical findings Figures 1 and 2 and after numerous appointments[ 3 , 5 ] – and 15 control patients with no history of cancer or any oral lesion, but possessing the same demographics, were chosen from patients assisted by the Orocentro Oral Diagnosis Clinic of Piracicaba Dental School.

Clinicopathological data were collected retrospectively from patient charts. The inclusion criteria for the sample was a clinical and histopathological diagnosis of PVL according to the World Health Organization.

We excluded patients that had an absence of saliva. Although all patients were female with no history of tobacco and alcohol consumption, these features were not part of our inclusion criteria but rather are peculiar features of patients with PVL.

After a mouthwash with 5 mL of drinking water for removal of oral residues, whole, unstimulated saliva produced over 5 min was collected in sterile plastic tubes of 50 mL. The supernatant was collected and protein concentrations were settled with a Bradford test Bio-Rad, Hercules, CA, United States prior to protein digestion.

All steps for peptides preparation and all instrument methods for the LTQ Orbitrap Velos were set up following the protocol established by Flores et al[ 25 ]. Peak lists were generated from the raw data files using Proteome Discoverer version 1.

A Comma-separated values file comprising the determined proteins and their normalised spectral counts have been created for 15 healthy patients control and 15 PVL patients PVL. Fold change FC calculation for proteins with differences in relation to abundance was performed according to the equation: Mean of abundance values.

Moreover, fold changes less than 1 were used the equation below: Finally, to develop a method to predict the probability of pertinence to one specified group, an analysis based on the regression logistic model was conducted in conjunction with the stepwise method for variable selection as proteins were identified.

Mean values are presented with the standard error. All thirty patients were females, with mean age of Demographic and clinicopathological data of the populations are shown in Tables 1 and 2.

A complete list of proteins and their respective normalized spectral counts in each patient is shown in Supplemental Table 1. Among these 31 proteins, 25 had higher abundance in the control group, and six proteins were higher in PVL group Table 3.

Logistic regression screening tests were used as a form of group differentiation and two potential biomarkers met the final prediction: When likelihood analysis was applied to the two variables selected stepwise within the logistic regression, the following logistic function was obtained: A negative logit indicated control group landmarks while a positive logit indicated PVL landmarks.

Combining the two selected variables in this study, a concordance index of The parameters selected by the stepwise method and their estimates are: The reliability values of the model built by the logistic regression test are: PVL is a well-recognized form of oral leukoplakia which presents with particular features and certain molecular aspects.

Previous studies have shown certain features of these intriguing lesion, where even no dysplastic lesions can present positivity for Mcm-2 positive, can be aneuploidy and can transform in cancer[ 3 , 5 ].

However, biomolecules and mechanisms involved in etiopathogenesis and progression remain obscure. A literature review of 84 English PVL articles revealed only 10 studies that described molecular aspects of PVL[ 3 , 5 , 10 , 20 , 26 – 31 ].

The approach presented here may combine this oral malignant condition as well as the secreted proteins associated with this lesion. In comparison to serum, saliva presents with a lower amount of informative analytes, which presents a major challenge for research[ 32 , 33 ].

Thus, saliva can be considered as the blood stream of the oral cavity and proteins with different profile levels can be detected; analyses of these proteins can lead to their association with pathologies, leading to the discovery of potential biomarkers[ 34 , 35 ].

Among the proteins identified in the saliva samples collected here, 31 proteins showed statistical significance difference in relation to abundance, with 25 proteins having higher abundance in the control group and six proteins having higher abundance in PVL group Table 3.

Based on these findings, both proteins can be considered as the first salivary proteins with biomarker potential involved in the etiology of PVL. AGT 61 kDa is a circulating protein, and mostly known for its role as a precursor of the renin-angiotensin-aldosterone system, where it is synthesized and secreted mostly by hepatocytes, adipocytes and astrocytes[ 35 – 37 ].

Physiologically, AGT is a unique precursor of the angiotensin peptides and the only natural renin substrate[ 36 ]. Moreover, AGT is derived from serine protease inhibitor, which has a role in blood pressure control as a potent vasoconstrictor of arteries and veins, as well as in prothrombotic action[ 37 , 38 ].

Interestingly, recent studies have also related AGT with in vitro cell inhibition of human endothelial proliferation, migration and angiogenesis[ 37 – 39 ]. Anti-tumoral effects of AGT – which include blocking of primary tumor growth, suppression of intratumoral vascularisation, and decreased number of metastases – were observed in in vivo models[ 37 , 39 ].

Moreover, AGT was found down-regulated in tissue samples of esophageal squamous cell carcinoma and in the serum of subjects with recurrent head and neck cancer, demonstrating that it may be normally involved in impeding tumorigenesis[ 38 , 40 ].

A previous study also demonstrated that women with low amount of AGT presented an elevated risk of breast cancer[ 38 , 41 ]. No difference was observed in the expression or abundance within the PVL group in relation to patients that developed oral cancer, but these results were expected since patients with PVL probably will develop cancer during follow-up.

The activity of DPP1 is crucial in the differentiation of promyelocytes into mature neutrophils, and in the production of neutrophil elastase, proteinase-3, and cathepsin G[ 42 , 43 ].

In addition to its involvement in physiological processes, an intrinsic relation among squamous carcinogenesis and DPP1 expression was demonstrated in relation to tumor growth and angiogenesis[ 45 ].

Among the tumors involved, squamous cell carcinoma of the oral cavity, nasopharynx and thyroid exhibited increased DPP1 expression when compared to control samples[ 45 ]. Nevertheless, DPP1 did not show an effect in the formation or progression in pancreatic endocrine tumors, presenting expression in innate immune cells[ 46 ].

Interestingly, dipeptidyl peptidase IV DPPIV is another cathepsin expressed in normal epithelial cells, but has decreased expression in various cancers, such as melanoma, lung and prostatic cancer suggesting that a decrease DPPIV expression can be a critical event during cancer progression[ 47 – 50 ].

In the present study, lower expression of DPP1 was found in PVL patients; although some articles demonstrated increased expression of this molecule and its association with tumor progression, one study showed a loss of DPP1 expression that was related with cancer[ 46 ].

No significant abundance differences were observed between PVL patients at various disease stages, including patients that developed oral cancer. Nevertheless, a deeper investigation of these proteins to analyze their role in PVL disease is necessary.

This study revealed evidence about the promising etiologic potential of the proteins AGT and DPP1, and how these biomolecules may be associated with the development of PVL. However, our study focused on only a limited number of patients, all of whom are undergoing a very dynamic disease process; a larger sample size and standardization of sample collection with successive investigations could improve future studies.

Moreover, more saliva samples would improve logit formula validation, an important step in following patients that go on to develop oral cancer. In conclusion, there were no known etiologic factors of PVL previously; however, close contact of saliva with the PVL lesions presented a potential source for the detection of possible biomolecules through salivary proteome examination.

Additional studies about the profile of the salivary proteome are necessary and may contribute to improving our understanding of this pattern of expression for AGT and DPP1. Proliferative verrucous leukoplakia PVL is a seldom variant of oral leukoplakia with an unique behavior characterized by persistent progression to malignancy.

This variability mostly depends on the time of patient follow-up and the criteria for diagnosis of PVL. Due to a lack of specific baseline characteristics, the PVL diagnosis is made retrospectively, based on observation of progressive clinical and microscopical characteristics of the lesions.

Initial focal involvement, geographic expansion multifocal over time, development of a warty appearance and finally, development of a cancer. Recently, the use of proteomic-based mass spectrometry MS has increased interest in salivary biomarkers for numerous diseases, including OSCC.

In the present study, lower expression of dipeptidyl peptidase 1 DPP1 was found in PVL patients; although some articles demonstrated increased expression of this molecule and its association with tumor progression.

The manuscript is interesting and presents a novel diagnostic tool. The purpose, background, and results of this study are interesting and this manuscript is well written.

Kong JX L- Editor: Academic Rules and Norms of This Article. Citation of this article. Low expression of angiotensinogen and dipeptidyl peptidase 1 in saliva of patients with proliferative verrucous leukoplakia.

Corresponding Author of This Article. Publishing Process of This Article. Research Domain of This Article. Dentistry, Oral Surgery and Medicine. A local dealer had to add the controller after it arrived for our test.

Our turnaround point for our road test was near Laughlin, Nev. Cajon Pass was a warm-up for testing the 5. On Highway 68, the 5. We also staked out a 7,foot stretch of the grade where we could safely climb the hill from a full stop and measure its performance using our VBOX kit.

Zero to 60 mph up the steady 5 percent grade took Those numbers, plus seat-of-the-pants feel, make us wonder how much Ford might be sandbagging the 5.

We also ran the same performance tests on level ground. The zero-to mph time with the trailer was cut almost in half, to just Our final confirmation of the tremendous towing performance and potential of the 5.

At the rear wheels, we measured a very healthy hp and pounds-feet of torque. A truck that drives this smoothly and comfortably, with very little driver fatigue, at max capacities is something quite special — even unusual in any truck segment.

The truck was also comfortable and relatively easy to manage in unloaded driving around Los Angeles. It was also fun to show off some of the 5. We averaged between 13 mpg and 17 mpg depending on traffic conditions, surface streets and highway driving.

Which engine should F buyers choose? If we were going to buy an F today, the 5. WOW is all I can say Mike I want this truck so bad. I have to wait 8 more months until I can get something new but I’m pretty sure I know what its going to be now.

This is why I love this site. Keep up the good work! Ford is really stepping up their powertrain program. Never have been a true Ford fan but i will give them credit for putting out not just 1, but 4 impressive powertrain options.

Thanks Mike for the write up.. A really nice looking truck with what sounds like to be a good engine, but the picture of the engine makes it look like it’s on life support with all those hoses.

I have to disagree with one thing – that if you are towing 5,, lbs regularly and unsure of the EcoBoost the 5L is for you. Most crew cab half tons do not have that much payload, and the truck still needs to hold the people.

And you haven’t put anything in the cab or bed. If you have lb payload. That leaves only lbs for passengers and cargo. Maybe if I was towing up to lbs occasionally, didn’t have many passengers or cargo to weigh me down, didn’t care about fuel economy, and was afraid of EB I don’t know why I would be I would go with the 5L.

The ecoboost IS Ford’s max tow engine. It is advertised as being the workhorse of the bunch. The torture tests show that it can handle the work. You appear to be from the school “that there is no displacement for replacement”.

That is your personal opinion and that is fine, but a journalist is suppose to be open minded and you have made this statement without even doing a comparsion test on the ecoboost.

Your reports at pickuptrucks. On the strength of your light duty shoot out I bought a 3. Now I really wish I had bought the 5. All it is, is a modern engine in a sea of dated ones. And the truck is far too ugly and overpriced to be taken seriously.

Are you kidding me? And on the MPG figures, one must keep in mind that Ford did not come to that mileage figure using 3. They used the tallest gear offered which is a 3.

So the mileage figures are deceiving. My truck will mostly be a daily driver but also horse hauler. The real problem of the 5L without the max tow package is the payload on the Supercrew, especially the 6.

You get at least pounds more payload with EB Maxt Tow, pounds more with a supercab, which is the limiting towing factor for almost all trucks. Oh, and then there is the wife, kids, firewood, bed cover, tools, cargo, etc that goes in the truck.

I also heard Mike say EcoBoost might be better in high altitude than the V8’s, and when looking at the 6. Carl What about this review made you feel as though this was an attack against the Ecoboost?

Mike acknowledge the capibility of the Ecoboost and even recommeded it as well. He’s just stating that the 5. And to say this new Ford engine is not impressive just show’s that you really are nothing more than a troll.

I’ve been keeping up with this engine on Ford Truck Fourms and many personal owners of this truck are achiveing between mpg around town and up to 23mpg on the high And if you don’t beleive me why don’t you read the fourms for yourself.

That’s pretty impressive that the 5. While I’m sure the 6. They’ve still got the Ecoboost and their own 6. It’s also worth mentioning that it beat the Tundra with 5. All we needed was a EB, a Ford 6.

Also another thing I was curious about It does sound like an impressive engine. To put it in perspective – I had a F with a 5. It only had Hp and got around 12 city and 16 highway. I’m getting 12 – 14 around town with my 5.

It does not make any sense that you can get a 36 gallon tank on this truck but not the EB 3. I can’t see why Ford would even offer the smaller tank. The tow package should come standard with the trailer brake controller, tow mirrors, and backup camera.

Mike – quote ” Despite a lack of luxury items” man – oh – man I’d love to have your job if you think this truck is lacking in luxury: Now, it’s worth mentioning that Ford takes their MPG measurements from a truck with the 3.

It wouldn’t surprise me if Ford’s MPG measurement with the 5. However, the only way to know for sure would be to have both trucks tested, since the EPA doesn’t test the other gear ratios.

It looks like no matter what engine you get, in the F, you can not go wrong. They are all winners! The people, that opt to buy another truck instead of the Ford F, will all be whiners kicking themselves for going against better judgement.

Impressive performance, especially after comparing it to the competition from the last big half ton shootout. The dyno numbers confirm that Ford isn’t sandbagging the numbers, perhaps it’s just a combination of linear power and good gearing.

Your articles are the best in the field! I just love the F with yhe 5. From the sound clips on You Tube it sounds so good as stock! I have seen here Israel an F with the older Mod engine and it sounded so good – it was completley stock- I know the 5.

My friends dad just bought a new Chevy silverado z71 ext. He was told he had the towing package,but it has the 3. His older 04 silverado had predrilled holes for his gooseneck,and a much heavier frame,needless to say he isn’t to pleased.

I also noticed on his new truck how poorly it was put together. The leftside fender had a place that was higher than the hood,and the rightside was level. It all started with him having to replace the intake on his old Crown Vic police car.

I’m not negative against EcoBoost. We have yet to do a long road test of the 3. But I have towed a 6, lb trailer with EB during Ford’s first drive for media and observed towing fuel economy during that brief drive was about the same as the 5.

I see no reason that the 5. This engine has headroom. I would love to see a comparison of a 5. Wow, either the rear-end is sagging with the trailer, or the rear fender wheel housing is smaller than the front I would say because it’s four-wheel drive.

They have more equipment and they burn more fuel in 4WD. Even if you kept it in 2WD the 4WD equipment will still be there to pack on the truck pounds. That said, I hope the 2WD is at least 20 highway mpg!

Thanks for the great read Mike. I can see for Ford half-ton buyers right now, it would be a tough choice between the 5. Personally, even though I’m a bit of a power freak, I would not go the 6.

Mike Levine, you mentioned the tranny shifted into 6th once you crested Cajon Pass. So this engine will steadily pull that weight and somewhat high profile trailer at 65 mph in overdrive on flat ground?

That would be as impressive as the uphill power imo. I do a lot of highway towing on flat ground, in traffic. The biggest issue with gassers is the constant downshifting or the inability to stay in OD pulling a heavy or high profile trailer at highway speed or for small increases in speed.

They usually have the power once the rpms get way up but not much under 2k rpm for maintaning highway speed in OD. In steady state driving at 65 mph on level ground, the truck had no issues running in 6th gear.